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Effect of cellular glutathione content on the induction of DNA double Strand breaks by 25 mev electrons.

Int. J. Radiat. Biol. 52, 185-190 (1987)
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The effect of endogenous glutathione (GSH) on the induction of DNA double strand breaks (dsb) by 25 MeV electrons was investigated using stationary haploid yeast cells defective in γglutamyl-cysteine-synthetase (gsh 1) containing less than 5 per cent of the normal GSH content. In gsh 1 cells the induction of dsb is increased by a factor of 1·5 under oxic and 1·8 under anoxic irradiation conditions: whereas the oxygen enhancement ratio was only slightly decreased (1·9) compared to wild-type cells (2·4).
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Publication type Article: Journal article
Document type Scientific Article
Reviewing status