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Han, H.B.* ; Xia, Z.L.* ; Chen, H.* ; Hou, C.* ; Li, W.B.

Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia.

Sci. China Life Sci. 54, 235-239 (2011)
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Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier. However, despite 16 years of research on a number of central nervous system disorders, an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme. Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system. To validate this technique, rats were subjected to a single intracranial (at the caudate nucleus), or intraperitoneal injection, of the compound citicoline, followed two hours later by a permanent middle cerebral artery occlusion (pMCAO). Results showed that 12 h after pMCAO, with 0.0025 g kg−1 citicoline, an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group. These results suggest that given the appropriate injection point, through SDD a pharmacologically effective concentration of citicoline can be administered.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter permanent middle cerebral artery occlusion; animal model; brain ischemic injury; citicoline therapy; MRI; neuroprotection
ISSN (print) / ISBN 1006-9305
e-ISSN 1862-2798
Quellenangaben Band: 54, Heft: 3, Seiten: 235-239 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed