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Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.
FEBS Lett. 250, 622-624 (1989)
Lectin stimulation of human T lymphocytes causes a 7-fold increase in the specific activities of GTP-cyclohydrolase and a 4-fold increase in the specific activities of sepiapterin reductase. GTP-cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities contunue to increase during the 72 h period measured. The specific activities of 6-pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP-cyclohydrolase and sepiapterin reductase.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0014-5793
Journal FEBS Letters
Quellenangaben Volume: 250, Issue: 2, Pages: 622-624
Reviewing status Peer reviewed