as soon as is submitted to ZB.
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells.
Stem Cells 33, 170-182 (2015)
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs and extrinsic signals, very few of which are known. β-catenin transduces extracellular Wnt signals, but also maintains adherens junctions integrity. Here, we identify for the first time the contribution of β-catenin transcriptional activity as opposed to its adhesion role in the development of the cerebral cortex by combining a novel β-catenin mutant allele with conditional inactivation approaches. Wnt/β-catenin signaling ablation leads to premature NPC differentiation, but, in addition, to a change in progenitor cell cycle kinetics and an increase in basally dividing progenitors. Interestingly, Wnt/β-catenin signaling affects the sequential fate switch of progenitors, leading to a shortened neurogenic period with decreased number of both deep and upper-layer neurons and later, to precocious astrogenesis. Indeed, a genome-wide analysis highlighted the premature activation of a corticogenesis differentiation program in the Wnt/β-catenin signaling-ablated cortex. Thus, β-catenin signaling controls the expression of a set of genes that appear to act downstream of canonical Wnt signaling to regulate the stage-specific production of appropriate progenitor numbers, neuronal subpopulations, and astroglia in the forebrain.
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Neural stem cell; Signal transduction; Neural differentiation; Cellular proliferation
ISSN (print) / ISBN 0737-1454
Journal Stem Cells
Quellenangaben Volume: 33, Issue: 1, Pages: 170-182
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)