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Seyfarth, K.* ; Poschmann, G.* ; Rozman, J. ; Fromme, T.* ; Rink, N.* ; Hofmann, A. ; Wurst, W. ; Stühler, K.* ; Klingenspor, M.

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice.

J. Nutr. Biochem. 26, 75-81 (2015)
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DJ-1 constitutes a ubiquitously expressed, oxidative stress-responsive protein with multiple functions. DJ-1 emerged as a candidate from our previous proteome analysis investigating alterations in the hypothalamus in three mouse strains differing in their susceptibility to diet-induced obesity (DIO). Validation studies demonstrated a high-fat diet (HFD)-induced shift in the DJ-1 isoform pattern in the hypothalamus and several other tissues of mice. Others found HFD-induced alterations in DJ-1 protein abundance in adipose tissue and pancreatic islets in wild-type rodents. Here, we investigated the gene-diet interaction by challenging Dj-1(-/-) mice with a HFD. We demonstrate that the development of diet-induced obesity (DIO) Dj-1(-/-) mice is according to wild-type mice with the exception of transient higher gains in fat mass at the expense of lean mass after 14 weeks of feeding.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dj-1 ; Diet-induced Obesity ; High-fat Diet ; Mice ; Neurodegeneration ; Park7
ISSN (print) / ISBN 0955-2863
e-ISSN 0955-2863
Quellenangaben Band: 26, Heft: 1, Seiten: 75-81 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed