Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation.
Cell Rep. 10, 131-139 (2015)
Master regulators of the epithelial-mesenchymal transition such as Twist1 and Snail1 have been implicated in invasiveness and the generation of cancer stem cells, but their persistent activity inhibits stem-cell-like properties and the outgrowth of disseminated cancer cells into macroscopic metastases. Here, we show that Twist1 activation primes a subset of mammary epithelial cells for stem-cell-like properties, which only emerge and stably persist following Twist1 deactivation. Consequently, when cells undergo a mesenchymal-epithelial transition (MET), they do not return to their original epithelial cell state, evidenced by acquisition of invasive growth behavior and a distinct gene expression profile. These data provide an explanation for how transient Twist1 activation may promote all steps of the metastatic cascade; i.e., invasion, dissemination, and metastatic outgrowth at distant sites.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Promotes Metastatic Colonization; Mesenchymal Transition; Breast-cancer; E-cadherin; Expression; Generation; Requires; Emt
ISSN (print) / ISBN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 10, Heft: 2, Seiten: 131-139
Verlag Cell Press ; Elsevier