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Loss, G.* ; Depner, M.* ; Ulfman, L.H.* ; van Neerven, R.J.* ; Hose, A.J.* ; Genuneit, J.* ; Karvonen, A.M.* ; Hyvärinen, A.* ; Kaulek, V.* ; Roduit, C.* ; Weber, J.* ; Lauener, R.* ; Pfefferle, P.I.* ; Pekkanen, J.* ; Vaarala, O.* ; Dalphin, J.-C.* ; Riedler, J.* ; Braun-Fahrländer, C.* ; von Mutius, E. ; Ege, M.J.

Consumption of unprocessed cow's milk protects infants from common respiratory infections.

J. Allergy Clin. Immunol. 135, 56-62 (2015)
Verlagsversion DOI
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background: Breast-feeding is protective against respiratory infections in early life. Given the co-evolutionary adaptations of humans and cattle, bovine milk might exert similar anti-infective effects in human infants. Objective: To study effects of consumption of raw and processed cow's milk on common infections in infants. Methods: The PASTURE birth cohort followed 983 infants from rural areas in Austria, Finland, France, Germany, and Switzerland, for the first year of life, covering 37,306 person-weeks. Consumption of different types of cow's milk and occurrence of rhinitis, respiratory tract infections, otitis, and fever were assessed by weekly health diaries. C-reactive protein levels were assessed using blood samples taken at 12 months. Results: When contrasted with ultra-heat treated milk, raw milk consumption was inversely associated with occurrence of rhinitis (adjusted odds ratio from longitudinal models [95% CI]: 0.71 [0.54-0.94]), respiratory tract infections (0.77 [0.59-0.99]), otitis (0.14 [0.05-0.42]), and fever (0.69 [0.47-1.01]). Boiled farm milk showed similar but weaker associations. Industrially processed pasteurized milk was inversely associated with fever. Raw farm milk consumption was inversely associated with C-reactive protein levels at 12 months (geometric means ratio [95% CI]: 0.66 [0.45-0.98]). Conclusions: Early life consumption of raw cow's milk reduced the risk of manifest respiratory infections and fever by about 30%. If the health hazards of raw milk could be overcome, the public health impact of minimally processed but pathogen-free milk might be enormous, given the high prevalence of respiratory infections in the first year of life and the associated direct and indirect costs.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Respiratory Infections ; Rhinitis ; Otitis ; Fever ; Inflammation ; C-reactive Protein ; Infancy ; Milk ; Prevention ; Epidemiology; 1st Year; Atopic Sensitization; Childhood Asthma; Viral-infections; Birth-cohort; Life; Children; Inflammation; Prevention; Proteins
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Quellenangaben Band: 135, Heft: 1, Seiten: 56-62 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed