Open Access Green as soon as Postprint is submitted to ZB.
beta-Cells at the crossroads: Choosing between insulin granule production and proliferation.
Diabetes Obes. Metab. 11, 54-64 (2009)
Pancreatic beta-cells are the sole source of insulin, the major hormonal regulator of glycaemia. In physiological and pathological conditions with increased insulin demand, beta-cells adjust their insulin output either through increased insulin secretory granule (ISG) biogenesis and secretion, or hyperplasia. Failure of these compensatory mechanisms eventually results in hyperglycaemia and diabetes mellitus. Both of these major adaptive behaviours are positively regulated by several extrinsic factors, such as glucose, GLP-1, insulin and growth hormones (GH). Still unclear, however, it is how beta-cells in response to these stimuli opt for one or the other strategy at a given time. Here we review recent advances concerning the factors and pathways that enhance ISG biogenesis and beta-cell replication, and propose the existence of 'switch factors' that play a key role in regulating the shift between these two adaptive responses.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1462-8902
Journal Diabetes, Obesity and Metabolism
Quellenangaben Volume: 11, Pages: 54-64
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)