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Hxt1, a monosaccharide transporter and sensor required for virulence of the maize pathogen Ustilago maydis.

New Phytol. 206, 1086-1100 (2015)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Summary: The smut Ustilago maydis, a ubiquitous pest of corn, is highly adapted to its host to parasitize on its organic carbon sources. We have identified a hexose transporter, Hxt1, as important for fungal development during both the saprophytic and the pathogenic stage of the fungus. Hxt1 was characterized as a high-affinity transporter for glucose, fructose, and mannose; {increment}hxt1 strains show significantly reduced growth on these substrates, setting Hxt1 as the main hexose transporter during saprophytic growth. After plant infection, {increment}hxt1 strains show decreased symptom development. However, expression of a Hxt1 protein with a mutation leading to constitutively active signaling in the yeast glucose sensors Snf3p and Rgt2p results in completely apathogenic strains. Fungal development is stalled immediately after plant penetration, implying a dual function of Hxt1 as transporter and sensor. As glucose sensors are only known for yeasts, 'transceptor' as Hxt1 may constitute a general mechanism for sensing of glucose in fungi. In U. maydis, Hxt1 links a nutrient-dependent environmental signal to the developmental program during pathogenic development.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ustilago Maydis ; Biotrophic Development ; Monosaccharide Sensor ; Monosaccharide Transport ; Plant Pathogen ; Transceptor; Yeast Saccharomyces-cerevisiae; Gene Replacement Mutants; Casein Kinase-i; Hexose Transporters; Arabidopsis-thaliana; Glucose Sensor; Uromyces-fabae; Mig1 Repressor; Hepatic Cells; Amino-acids
Reviewing status