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Borg, D.J.* ; Bonifacio, E.*

The use of biomaterials in islet transplantation.

Curr. Diab. Rep. 11, 434-444 (2011)
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Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function. Therefore, the use of accessory therapy and biomaterials to protect islets and improve islet function has definite therapeutic potential. Here we review the application of niche accessory cells and factors, as well as the use of biomaterials as carriers or capsules, for pancreatic islet transplantation.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Quellenangaben Volume: 11, Issue: 5, Pages: 434-444 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)