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Monti, P.* ; Heninger, A.K.* ; Bonifacio, E.*

Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus.

Curr. Diab. Rep. 9, 113-118 (2009)
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Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulin-producing beta cells is still poorly understood. T cells potentially able to recognize and destroy beta cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM.
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Publication type Article: Journal article
Document type Scientific Article
Reviewing status
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)