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Lingwood, D.* ; Binnington, B.* ; Róg, T.* ; Vattulainen, I.* ; Grzybek, M.* ; Coskun, Ü.* ; Lingwood, C.A.* ; Simons, K.*

Cholesterol modulates glycolipid conformation and receptor activity.

Nat. Chem. Biol. 7, 260-262 (2011)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1552-4450
e-ISSN 1552-4469
Zeitschrift Nature Chemical Biology
Quellenangaben Band: 7, Heft: 5, Seiten: 260-262 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Basingstoke
Begutachtungsstatus
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)