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Lingwood, D.* ; Binnington, B.* ; Róg, T.* ; Vattulainen, I.* ; Grzybek, M.* ; Coskun, Ü.* ; Lingwood, C.A.* ; Simons, K.*

Cholesterol modulates glycolipid conformation and receptor activity.

Nat. Chem. Biol. 7, 260-262 (2011)
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Open Access Green as soon as Postprint is submitted to ZB.
We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1552-4450
e-ISSN 1552-4469
Quellenangaben Volume: 7, Issue: 5, Pages: 260-262 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Basingstoke
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)