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Czogalla, A.* ; Grzybek, M.* ; Jones, W.* ; Coskun, Ü.*

Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids.

Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1049-1059 (2014)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The cell membrane serves, at the same time, both as a barrier that segregates as well as a functional layer that facilitates selective communication. It is characterized as much by the complexity of its components as by the myriad of signaling process that it supports. And, herein lays the problems in its study and understanding of its behavior - it has a complex and dynamic nature that is further entangled by the fact that many events are both temporal and transient in their nature. Model membrane systems that bypass cellular complexity and compositional diversity have tremendously accelerated our understanding of the mechanisms and biological consequences of lipid-lipid and protein-lipid interactions. Concurrently, in some cases, the validity and applicability of model membrane systems are tarnished by inherent methodical limitations as well as undefined quality criteria. In this review we introduce membrane model systems widely used to study protein-lipid interactions in the context of key parameters of the membrane that govern lipid availability for peripheral membrane proteins. This article is part of a Special Issue entitled Tools to study lipid functions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Lipid Identity ; Lipid Presentation ; Membrane ; Model Membrane System ; Phospholipid ; Protein–lipid Interaction; Giant Unilamellar Vesicles; Fluorescence Correlation Spectroscopy; Hybrid Bilayer-membranes; Atomic-force Microscopy; Supported Phospholipid-bilayers; Pleckstrin Homology Domains; Polymer-cushioned Bilayers; Surface-plasmon Resonance; Pressure-area Measurement; Oil-water Interface
ISSN (print) / ISBN 1388-1981
Zeitschrift Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Quellenangaben Band: 1841, Heft: 8, Seiten: 1049-1059 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
German Center for Diabetes Reseach (DZD)