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Brown adipose tissue harbors a distinct sub-population of regulatory T cells.

PLoS ONE 10:e0118534 (2015)
Publishers Version DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
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Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Insulin-resistance; Adipocytes; Obesity; Macrophages; Thermogenesis; Inflammation; Activation; Mice; Recruitment; Expression
Reviewing status