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Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.

Nat. Neurosci. 18, 490-492 (2015)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
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Publication type Article: Journal article
Document type Scientific Article
Reviewing status