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Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.
Nat. Neurosci. 18, 490-492 (2015)
We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
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Publication type Article: Journal article
Document type Scientific Article