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Phieler, J.* ; Garcia-Martin, R.* ; Lambris, J.D.* ; Chavakis, T.*

The role of the complement system in metabolic organs and metabolic diseases.

Semin. Immunol. 25, 47-53 (2013)
DOI Order publishers version
Open Access Green as soon as Postprint is submitted to ZB.
Emerging evidence points to a close crosstalk between metabolic organs and innate immunity in the course of metabolic disorders. In particular, cellular and humoral factors of innate immunity are thought to contribute to metabolic dysregulation of the adipose tissue or the liver, as well as to dysfunction of the pancreas; all these conditions are linked to the development of insulin resistance and diabetes mellitus. A central component of innate immunity is the complement system. Interestingly, the classical view of complement as a major system of host defense that copes with infections is changing to that of a multi-functional player in tissue homeostasis, degeneration, and regeneration. In the present review, we will discuss the link between complement and metabolic organs, focusing on the pancreas, adipose tissue, and liver and the diverse effects of complement system on metabolic disorders.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adipose Tissue ; Complement ; Diabetes ; Insulin Resistance ; Liver ; Pancreas ; Steatosis
ISSN (print) / ISBN 1044-5323
e-ISSN 1044-5323
Quellenangaben Volume: 25, Issue: 1, Pages: 47-53 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)