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Pilot study of serum inhibin B as a potential marker of testosterone doping in weight lifting men.
Clin. J. Sport Med. 20, 117-119 (2010)
OBJECTIVE: The aim of this study was to explore effectors of the pituitary-testicular axis suitable as potential biochemical markers to screen for testosterone doping. DESIGN: Pilot study with male bodybuilding athletes with a self-reported history of testosterone doping (repeated intramuscular administration of testosterone preparations, last injection 8 weeks or less ago) compared with an equal sized control group matched for sex, age, and body mass index. SETTING: Endocrine outpatients. PARTICIPANTS: Fifteen healthy young men of white background. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Inhibin B, testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH). RESULTS: Although the levels of testosterone, LH, and FSH did not differ between the 2 groups, the serum concentrations of inhibin B in individuals with a history of testosterone doping were exclusively at or below the lower limit of the normal range for adult men (100-400 pg/mL). Inhibin B was significantly lower in those men who used testosterone for weight lifting (76.1 +/- 36.3 ng/L [mean +/- SD]) than in controls (182.1 +/- 35.4 ng/L). CONCLUSION: A low concentration of serum inhibin B may reflect the application of exogenous testosterone and appears to be a potential marker associated with anabolic androgenic steroid doping.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1050-642X
Quellenangaben Volume: 20, Issue: 2, Pages: 117-119
Publisher Lippincott Williams & Wilkins
Publishing Place Hagerstown, Md.
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)