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Kanczkowski, W.* ; Zacharowski, K.* ; Bornstein, S.R.*

Role of toll-like receptors and inflammation in adrenal gland insufficiency.

Neuroimmunomodulation 17, 180-183 (2010)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Adrenal gland insufficiency - the clinical manifestation of deficient production or action of adrenal steroids - is a life-threatening disorder. Among many factors which can predispose to primary adrenal failure, an autoimmune adrenalitis and infectious agents play a major role. The initial host defense against bacterial infections is executed primarily by the pattern recognition receptors, e.g. Toll-like receptors (TLRs), expressed in cells from the innate immune system. Upon activation, TLRs have been found to regulate various levels of innate and adaptive immunity as well as control tissue inflammation. TLRs are implicated in adrenal cell turnover and steroidogenesis during inflammation. Therefore, TLRs play a crucial role in the activation of adrenal inflammation mediating adrenal gland dysfunction during septicemia.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
ISSN (print) / ISBN 1021-7401
e-ISSN 1423-0216
Zeitschrift Neuroimmunomodulation
Quellenangaben Band: 17, Heft: 3, Seiten: 180-183 Artikelnummer: , Supplement: ,
Verlag Karger
Verlagsort Basel ; Freiburg, Br. [u.a]
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)