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Lachenmayer, A.* ; Lichtenauer, U.D.* ; Cox, T.* ; Schott, M.* ; Malendowicz, L.K.* ; Goretzki, P.E.* ; Cupisti, K.* ; Scherbaum, W.A.* ; Bornstein, S.R.* ; Willenberg, H.S.*

Nestin as a marker in the classification of adrenocortical tumors.

Horm. Metab. Res. 41, 397-401 (2009)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Expression of the intermediate filament, nestin, was long believed to be restricted to neuroectodermal stem cells. However, nestin expression has recently been detected in several tumors. Since adrenocortical carcinoma, a tumor entity still very difficult to classify, may gain the ability to aberrantly express neuroectodermal proteins including chromogranin A and synaptophysin, we asked the question whether nestin might also be detected in adrenocortical carcinomas, and if so, whether it might serve as a tool for clinical pathology. Therefore, we studied the expression of nestin in normal adrenal glands, adrenocortical adenomas, and adrenocortical cancers using specific immunohistochemistry and semi-quantitative reverse transcriptase-polymerase chain reaction. Immunostaining was nestin-positive in 1 out of 9 normal adrenal glands (11%), 2 out of 20 adrenocortical adenomas (10%), and 13 out of 16 adrenocortical carcinomas (81%). Expression of nestin mRNA could be detected in all microdissected tissues, independently of their grade of dedifferentiation. We conclude that our findings provide further evidence that nestin, as a marker, is not restricted to neuronal stem cells and nestin expression is worth to be studied in adrenocortical tumors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0018-5043
e-ISSN 1439-4286
Quellenangaben Band: 41, Heft: 5, Seiten: 397-401 Artikelnummer: , Supplement: ,
Verlag Thieme
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)