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Schwarz, P.E.* ; Li, J.* ; Reimann, M.* ; Schutte, A.E.* ; Bergmann, A.* ; Hanefeld, M.* ; Bornstein, S.R.* ; Schulze, J.* ; Tuomilehto, J.* ; Lindstrom, J.*

The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes.

J. Clin. Endocrinol. Metab. 94, 920-926 (2009)
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Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE: The Finnish Diabetes Risk Score (FINDRISC) questionnaire is a practical screening tool to estimate the diabetes risk and the probability of asymptomatic type 2 diabetes. In this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes risk. DESIGN: Data of 771 and 526 participants in a cross-sectional survey (1996) and a cohort study (1997-2000), respectively, were used for the analysis. Data on the FINDRISC and oral glucose tolerance test parameters were available from each participant. The predictive value of the FINDRISC was cross-sectionally evaluated using the area under the curve-receiver operating characteristics method and by correlation analyses. A validation of the cross-sectional results was performed on the prospective data from the cohort study. RESULTS: The FINDRISC was significantly correlated with markers of insulin resistance. The receiver operating characteristics-area under the curve for the prediction of a homeostasis model assessment insulin resistance index of more than five was 0.78 in the cross-sectional survey and 0.74 at baseline of the cohort study. Moreover, the FINDRISC at baseline was significantly associated with disease evolution (P < 0.01), which was defined as the change of glucose tolerance during the 3 yr follow-up. CONCLUSIONS: The results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Quellenangaben Volume: 94, Issue: 3, Pages: 920-926 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Bethesda, Md.
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)