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Riemer, J.* ; Schwarzländer, M.* ; Conrad, M. ; Herrmann, J.M.*

Thiol switches in mitochondria: Operation and physiological relevance.

Biol. Chem. 396, 465-482 (2015)
Publ. Version/Full Text DOI
Open Access Green as soon as Postprint is submitted to ZB.
Mitochondria are a major source of reactive oxygen species (ROS) in the cell, particularly of superoxide and hydrogen peroxide. A number of dedicated enzymes regulate the conversion and consumption of superoxide and hydrogen peroxide in the intermembrane space and the matrix of mitochondria. Nevertheless, hydrogen peroxide can also interact with many other mitochondrial enzymes, particularly those with reactive cysteine residues, modulating their reactivity in accordance with changes in redox conditions. In this review we will describe the general redox systems in mitochondria of animals, fungi and plants and discuss potential target proteins that were proposed to contain regulatory thiol switches.
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Publication type Article: Journal article
Document type Review
Keywords Glutathione ; Hydrogen Peroxide ; Mitochondria ; Nadph ; Reactive Oxygen Species ; Redox Regulation ; Ros ; Signaling ; Thiol Switch; Branched-chain Aminotransferase; Muscle Creatine-kinase; Resistant Alternative Oxidase; Ischemia-reperfusion Injury; Ascorbate-glutathione Cycle; Disulfide Bond Formation; Respiratory Complex-i; Active-site Cysteine; Intermembrane Space; Oxidative Stress
ISSN (print) / ISBN 1431-6730
e-ISSN 1437-4315
Quellenangaben Volume: 396, Issue: 5, Pages: 465-482 Article Number: , Supplement: ,
Publisher de Gruyter
Publishing Place Berlin
Reviewing status Peer reviewed