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Ilegems, E.* ; Dicker, A.* ; Speier, S.* ; Sharma, A.* ; Bahow, A.* ; Edlund, P.K.* ; Leibiger, I.B.* ; Berggren, P.O.*

Reporter islets in the eye reveal the plasticity of the endocrine pancreas.

Proc. Natl. Acad. Sci. U.S.A. 110, 20581-20586 (2013)
DOI Verlagsversion bestellen
The islets of Langerhans constitute the endocrine part of the pancreas and are responsible for maintenance of blood glucose homeostasis. They are deeply embedded in the exocrine pancreas, limiting their accessibility for functional studies. Understanding regulation of function and survival and assessing the clinical outcomes of individual treatment strategies for diabetes requires a monitoring system that continuously reports on the endocrine pancreas. We describe the application of a natural body window that successfully reports on the properties of in situ pancreatic islets. As proof of principle, we transplanted "reporter islets" into the anterior chamber of the eye of leptin-deficient mice. These islets displayed obesity-induced growth and vascularization patterns that were reversed by leptin treatment. Hence, reporter islets serve as optically accessible indicators of islet function in the pancreas, and also reflect the efficacy of specific treatment regimens aimed at regulating islet plasticity in vivo.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Beta Cell Mass ; In Vivo Imaging ; Islet Grafts ; Ob/ob Mouse ; Pharmacologic Treatment
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Quellenangaben Band: 110, Heft: 51, Seiten: 20581-20586 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)