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Wieduwild, R.* ; Lin, W.* ; Boden, A.* ; Kretschmer, K.* ; Zhang, Y.*

A repertoire of peptide tags for controlled drug release from injectable noncovalent hydrogel.

Biomacromolecules 15, 2058-2066 (2014)
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Open Access Green as soon as Postprint is submitted to ZB.
A repertoire of conjugable tags for controlling the release of drugs from biomaterials is highly interesting for the development of combinatorial drug administration techniques. This paper describes such a system of 11 peptide tags derived from our previous work on a physical hydrogel system cross-linked through peptide-heparin interactions. The release kinetics of the tags correlate well with their affinity to heparin and obey Fick's second law of diffusion, with the exception of the ATIII peptide, which displays a stable release profile close to a zero-order reaction. A system for release experiments over seven months was built, using the hydrogel matrix as a barrier between the reservoirs of tagged compounds and supernatant. The gel matrix can be injected without affecting the releasing properties. A tagged cyclosporin A derivative was also tested, and its release was monitored by measuring its biological activity. This work represents a design of biomaterials with an integral system of drug delivery, where both the assembly process of the matrix and affinity capture/release of tagged compounds are based on the noncovalent interaction of heparin with one class of peptides.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1525-7797
e-ISSN 1526-4602
Quellenangaben Volume: 15, Issue: 6, Pages: 2058-2066 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Publishing Place Washington, DC
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)