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Petzold, C.* ; Riewaldt, J.* ; Watts, D.* ; Sparwasser, T.* ; Schallenberg, S.* ; Kretschmer, K.*

Foxp3+ regulatory T cells in mouse models of type 1 diabetes.

J. Diabetes Res. 2013:940710 (2013)
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Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4(+)CD25(+) regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3(+) Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3(+) Treg cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 2314-6753
e-ISSN 2314-6745
Quellenangaben Band: 2013, Heft: , Seiten: , Artikelnummer: 940710 Supplement: ,
Verlag Hindawi
Verlagsort New York, NY [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)