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Buters, J.T.M.* ; Kasche, A.* ; Weichenmeier, I.* ; Schober, W.* ; Klaus, S.* ; Traidl-Hoffmann, C.* ; Menzel, A.* ; Huss-Marp, J.* ; Krämer, U.* ; Behrendt, H.

Year-to-year variation in release of Bet v 1 allergen from birch pollen: Evidence for geographical differences between West and South Germany.

Int. Arch. Allergy Immunol. 145, 122-130 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The release of the aeroallergen Bet v 1 from pollen is a major determinant in the etiology of allergic airway disease due to birch pollen. OBJECTIVE: We determined the release of the major birch pollen allergen Bet v 1 from pollen of birch trees growing in 2 different geographic regions in Germany for 2 consecutive years. METHODS: Catkins were collected during pollination in 2002 and 2003 from 82 healthy trees in South (Munich) and West Germany (North Rhine-Westphalia). The release of Bet v 1 from pollen samples was determined by a Bet v 1-specific ELISA. RESULTS: Pollen from South Germany released about 3 times more Bet v 1 than those from West Germany in both 2002 and 2003 (p = 0.034 and p = 0.007, respectively). This was independent of the number of pollen during the pollen flight season. In 2003, the release of Bet v 1 from pollen was more than 5 times higher than in 2002 in both regions (South Germany 6.1 times, p < 0.001; West Germany 5.4 times, p = 0.003). CONCLUSIONS: Despite large individual differences, there seem to be regional and year-to-year variations in Bet v 1 release from birch pollen. Therefore, the combination of pollen count and release of Bet v 1 from this pollen must be assessed to estimate Bet v 1 exposure reliably. 2007 S. Karger AG, Basel
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Publication type Article: Journal article
Document type Scientific Article
Keywords Birch; Pollen; Bet v 1; Regional; Seasonal
ISSN (print) / ISBN 1018-2438
e-ISSN 1423-0097
Quellenangaben Volume: 145, Issue: 2, Pages: 122-130 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Basel ; Freiburg [Breisgau] ; Paris ; London ; New York ; Bangalore ; Bangkok ; Singapore ; Tokyo ; Sydney
Reviewing status Peer reviewed
Institute(s) CCG Environmental Dermatology and Allergology (ILBD-KAU)
Institute of Epidemiology (EPI)