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Bork, U.* ; Grützmann, R.* ; Rahbari, N.N.* ; Schölch, S.* ; Distler, M.* ; Reissfelder, C.* ; Koch, M.* ; Weitz, J.*

Prognostic relevance of minimal residual disease in colorectal cancer.

World J. Gastroenterol. 20, 10296-10304 (2014)
DOI Order publishers version
Presence of occult minimal residual disease in patients with colorectal cancer (CRC) has a strong prognostic impact on survival. Minimal residual disease plays a major role in disease relapse and formation of metastases in CRC. Analysis of circulating tumor cells (CTC) in the blood is increasingly used in clinical practice for disease monitoring of CRC patients. In this review article the role of CTC, disseminated tumor cells (DTC) in the bone marrow and micrometastases and isolated tumor cells (ITC) in the lymph nodes will be discussed, including literature published until September 2013. Occult disease is a strong prognostic marker for patient survival in CRC and defined by the presence of CTC in the blood, DTC in the bone marrow and/or micrometastases and ITC in the lymph nodes. Minimal residual disease could be used in the future to identify patient groups at risk, who might benefit from individualized treatment options.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Circulating Tumor Cells ; Colorectal Cancer ; Disseminated Tumor Cells ; Isolated Tumor Cells ; Micrometastases ; Minimal Residual Disease ; Occult Disease
ISSN (print) / ISBN 1007-9327
e-ISSN 2219-2840
Quellenangaben Volume: 20, Issue: 30, Pages: 10296-10304 Article Number: , Supplement: ,
Publisher WJG Press
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)