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Franquelim, H.G.* ; Linko, V.* ; Czogalla, A.* ; Dietz, H.* ; Schwille, P.*

Synthetic membrane curvature-inducing DNA origami scaffolds.

Biophys. J. 106:617a (2014)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Biological membranes are dynamic cellular barriers that suffer deformation and bending. Despite huge effort in identifying the general elements involved in membrane curvature, the physical-chemical basis of curvature induction is still poorly understood. In this work, we fill this gap by engineering a minimal curvature-inducing system. Due to its exclusive nanoengineering properties, DNA origami technology will be utilized to build minimal curvature-inducing scaffoldings. This state-of-the-art technology enables the folding of long strands of DNA into nano-objects with defined shapes by using sequence-specific short DNA staples.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0006-3495
e-ISSN 1542-0086
Zeitschrift Biophysical Journal
Quellenangaben Band: 106, Heft: 2, Seiten: , Artikelnummer: 617a Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)