Open Access Green as soon as Postprint is submitted to ZB.
Synthetic membrane curvature-inducing DNA origami scaffolds.
Biophys. J. 106:617a (2014)
Biological membranes are dynamic cellular barriers that suffer deformation and bending. Despite huge effort in identifying the general elements involved in membrane curvature, the physical-chemical basis of curvature induction is still poorly understood. In this work, we fill this gap by engineering a minimal curvature-inducing system. Due to its exclusive nanoengineering properties, DNA origami technology will be utilized to build minimal curvature-inducing scaffoldings. This state-of-the-art technology enables the folding of long strands of DNA into nano-objects with defined shapes by using sequence-specific short DNA staples.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0006-3495
Journal Biophysical Journal
Quellenangaben Volume: 106, Issue: 2, Article Number: 617a
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)