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Franquelim, H.G.* ; Linko, V.* ; Czogalla, A.* ; Dietz, H.* ; Schwille, P.*

Synthetic membrane curvature-inducing DNA origami scaffolds.

Biophys. J. 106:617a (2014)
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Biological membranes are dynamic cellular barriers that suffer deformation and bending. Despite huge effort in identifying the general elements involved in membrane curvature, the physical-chemical basis of curvature induction is still poorly understood. In this work, we fill this gap by engineering a minimal curvature-inducing system. Due to its exclusive nanoengineering properties, DNA origami technology will be utilized to build minimal curvature-inducing scaffoldings. This state-of-the-art technology enables the folding of long strands of DNA into nano-objects with defined shapes by using sequence-specific short DNA staples.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0006-3495
e-ISSN 1542-0086
Quellenangaben Volume: 106, Issue: 2, Pages: , Article Number: 617a Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)