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Mechanistic modelling of radiation-induced bystander effects.

Radiat. Prot. Dosim. 166, 148-151 (2015)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A model of radiation-induced bystander effects is presented that explicitly takes into account the transient nature of bystander signal emission post-irradiation, signal lifetime and the non-linear cellular response to the signals. Data are analysed on mutagenesis induced in human lymphoblasts in medium transfer experiments, in which the signal build-up time, medium dilution and the duration of reporter cells' exposure to the medium were varied. The model implies that the cellular release of bystander signals decreases rather slowly, with a characteristic time of about a day, whereas the signal itself decays with a lifetime of about an hour.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Quellenangaben Band: 166, Heft: 1-4, Seiten: 148-151 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed