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Mons, U.* ; Müezzinler, A.* ; Gellert, C.* ; Schöttker, B.* ; Abnet, C.C.* ; Bobak, M.* ; de Groot, L.* ; Freedman, N.D.* ; Jansen, E.* ; Kee, F.* ; Kromhout, D.* ; Kuulasmaa, K.* ; Laatikainen, T.* ; O'Doherty, M.G.* ; Bueno-de-Mesquita, H.B.* ; Orfanos, P.* ; Peters, A. ; van der Schouw, Y.T.* ; Wilsgaard, T.* ; Wolk, A.* ; Trichopoulou, A.* ; Boffetta, P.* ; Brenner, H.* ; CHANCES Consortium (*)

Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium.

BMJ 350:h1551 (2015)
Verlagsversion DOI
Creative Commons Lizenzvertrag
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
OBJECTIVE: To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures. DESIGN: Individual participant meta-analysis using data from 25 cohorts participating in the CHANCES consortium. Data were harmonised, analysed separately employing Cox proportional hazard regression models, and combined by meta-analysis. RESULTS: Overall, 503 905 participants aged 60 and older were included in this study, of whom 37 952 died from cardiovascular disease. Random effects meta-analysis of the association of smoking status with cardiovascular mortality yielded a summary hazard ratio of 2.07 (95% CI 1.82 to 2.36) for current smokers and 1.37 (1.25 to 1.49) for former smokers compared with never smokers. Corresponding summary estimates for risk advancement periods were 5.50 years (4.25 to 6.75) for current smokers and 2.16 years (1.38 to 2.39) for former smokers. The excess risk in smokers increased with cigarette consumption in a dose-response manner, and decreased continuously with time since smoking cessation in former smokers. Relative risk estimates for acute coronary events and for stroke events were somewhat lower than for cardiovascular mortality, but patterns were similar. CONCLUSIONS: Our study corroborates and expands evidence from previous studies in showing that smoking is a strong independent risk factor of cardiovascular events and mortality even at older age, advancing cardiovascular mortality by more than five years, and demonstrating that smoking cessation in these age groups is still beneficial in reducing the excess risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rate Advancement Periods; Myocardial-infarction; Cigarette-smoking; United-states; Risk-factors; Health; Disease; Population; Stroke; Women
ISSN (print) / ISBN 0959-8138
e-ISSN 1756-1833
Zeitschrift BMJ
Quellenangaben Band: 350, Heft: , Seiten: , Artikelnummer: h1551 Supplement: ,
Verlag British Medical Association
Verlagsort London
Begutachtungsstatus Peer reviewed