PuSH - Publikationsserver des Helmholtz Zentrums München

Marr, C.* ; Müller-Linow, M.* ; Hütt, M.-T.*

Regularizing capacity of metabolic networks.

Phys. Rev. E 75:041917 (2007)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Despite their topological complexity almost all functional properties of metabolic networks can be derived from steady-state dynamics. Indeed, many theoretical investigations (like flux-balance analysis) rely on extracting function from steady states. This leads to the interesting question as to how metabolic networks avoid complex dynamics and maintain a steady-state behavior. Here, we expose metabolic network topologies to binary dynamics generated by simple local rules. We find that the networks' response is highly specific: Complex dynamics are systematically reduced on metabolic networks compared to randomized networks with identical degree sequences. Already small topological modifications substantially enhance the capacity of a network to host complex dynamic behavior and thus reduce its regularizing potential. This exceptionally pronounced regularization of dynamics encoded in the topology may explain why steady-state behavior is ubiquitous in metabolism.
Weitere Metriken?
Icb_extern Icb_qscd
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1063-651X
e-ISSN 1550-2376
Zeitschrift Physical Review E
Quellenangaben Band: 75, Heft: , Seiten: , Artikelnummer: 041917 Supplement: ,
Verlag American Physical Society (APS)
Verlagsort Melville, NY
Begutachtungsstatus Peer reviewed