PuSH - Publikationsserver des Helmholtz Zentrums München

Marr, C.* ; Müller-Linow, M.* ; Hütt, M.-T.*

Regularizing capacity of metabolic networks.

Phys. Rev. E 75:041917 (2007)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Despite their topological complexity almost all functional properties of metabolic networks can be derived from steady-state dynamics. Indeed, many theoretical investigations (like flux-balance analysis) rely on extracting function from steady states. This leads to the interesting question as to how metabolic networks avoid complex dynamics and maintain a steady-state behavior. Here, we expose metabolic network topologies to binary dynamics generated by simple local rules. We find that the networks' response is highly specific: Complex dynamics are systematically reduced on metabolic networks compared to randomized networks with identical degree sequences. Already small topological modifications substantially enhance the capacity of a network to host complex dynamic behavior and thus reduce its regularizing potential. This exceptionally pronounced regularization of dynamics encoded in the topology may explain why steady-state behavior is ubiquitous in metabolism.
Altmetric
Weitere Metriken?
Tags
Icb_extern Icb_qscd
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1063-651X
e-ISSN 1550-2376
Zeitschrift Physical Review E
Quellenangaben Band: 75, Heft: , Seiten: , Artikelnummer: 041917 Supplement: ,
Verlag American Physical Society (APS)
Verlagsort Melville, NY
Begutachtungsstatus Peer reviewed