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Marcos, V.* ; Zhou-Suckow, Z.* ; Yildirim, A.Ö. ; Bohla, A. ; Hector, A.* ; Vitkov, L.* ; Krautgartner, W.D.* ; Stoiber, W.* ; Griese, M.* ; Eickelberg, O. ; Mall, M.A.* ; Hartl, D.*

Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction.

Mediators Inflamm. 2015:408935 (2015)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Chronic obstructive lung disease determines morbidity and mortality of patients with cystic fibrosis (CF). CF airways are characterized by a nonresolving neutrophilic inflammation. After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs). NETs have been described to act in a beneficial way for innate host defense by bactericidal, fungicidal, and virucidal actions. On the other hand, excessive NET formation has been linked to the pathogenesis of autoinflammatory and autoimmune disease conditions. We quantified free DNA structures characteristic of NETs in airway fluids of CF patients and a mouse model with CF-like lung disease. Free DNA levels correlated with airflow obstruction, fungal colonization, and CXC chemokine levels in CF patients and CF-like mice. When viewed in combination, our results demonstrate that neutrophilic inflammation in CF airways is associated with abundant free DNA characteristic for NETosis, and suggest that free DNA may be implicated in lung function decline in patients with CF.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Neutrophil Extracellular Traps; Surfactant-protein-d; Lung-disease; Molecular-mechanisms; Inflammatory Markers; Overexpressing Mice; Chronic-bronchitis; Mitochondrial-dna; Release; Sputum
ISSN (print) / ISBN 0962-9351
e-ISSN 1466-1861
Quellenangaben Band: 2015, Heft: , Seiten: , Artikelnummer: 408935 Supplement: ,
Verlag Hindawi
Verlagsort Sylvania, Ohio
Begutachtungsstatus Peer reviewed