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Aumann, N.* ; Baumeister, S.E.* ; Rettig, R.* ; Lieb, W.* ; Werner, A.* ; Döring, A. ; Peters, A. ; Koenig, W.* ; Hannemann, A.* ; Wallaschofski, H.* ; Nauck, M.* ; Stracke, S.* ; Völzke, H.* ; Meisinger, C.

Regional variation of chronic kidney disease in Germany: Results from two population-based surveys.

Kidney Blood Press. Res. 40, 231-243 (2015)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Background/Aims: Due to the increasing prevalence of risk factors for chronic kidney disease (CKD), kidney dysfunction becomes a major public health problem. We investigated the CKD prevalence and determined to what extent the variation of risk factors explains the different CKD prevalence in Germany. Methods: We analyzed data from 6,054 participants, aged 31 to 82 years, from the Study of Health in Pomerania (SHIP-1) in Northeast Germany and the Cooperative Health Research in the Region of Augsburg (KORA F4) Study in Southern Germany. Regional differences in selected percentiles corresponding to the cutpoints for estimated glomerular filtration rate (eGFR, <60 ml/min per 1.73 m2) and albumin-to-creatinine ratio (ACR, ≥30 mg/g) were tested using quantile regression models that adjusted for CKD risk factors. Results: The prevalence of decreased eGFRcreatinine-cystatinC (5.9 vs. 3.1 %, p <0.001) and albuminuria (20.2 vs. 8.8 %, p<0.001) were higher in SHIP-1 than in KORA F4. The differential distribution of risk factors explained 18-21% of the regional differences of decreased eGFRcreatinine-cystatinC and high ACR. Conclusions: The CKD prevalence is higher in Northeast than in Southern Germany. Differences in the prevalence of risk factors partly explain the higher disease burden of CKD in Northeast than in Southern Germany.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Albuminuria ; Chronic Kidney Disease ; Cohort Study ; Creatinine ; Cystatin C ; Egfr ; Prevalence; Glomerular-filtration-rate; Serum Cystatin-c; Cooked-meat Meal; Cardiovascular-disease; Waist Circumference; Renal-function; Risk-factors; Follow-up; Prevalence; Creatinine
ISSN (print) / ISBN 1420-4096
e-ISSN 1423-0143
Quellenangaben Volume: 40, Issue: 3, Pages: 231-243 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Basel
Reviewing status Peer reviewed