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Selmansberger, M. ; Kaiser, J.C. ; Hess-Rieger, J. ; Güthlin, D. ; Likhtarov, I.* ; Shpak, V.* ; Tronko, M.* ; Brenner, A.* ; Abend, M.* ; Blettner, M.* ; Unger, K. ; Jacob, P. ; Zitzelsberger, H.

Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas.

Carcinogenesis 36, 748-756 (2015)
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Open Access Gold (Paid Option)
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A previous study on papillary thyroid carcinomas (PTC) in young patients who were exposed to (131)Iodine from the Chernobyl fallout revealed an exclusive gain of chromosomal band 7q11.23 in exposed cases compared to an age-matched control cohort. CLIP2, a gene located within band 7q11.23 was shown to be differentially expressed between exposed and non-exposed cases at mRNA and protein level. Therefore, a standardized procedure for CLIP2 typing of PTCs has been developed in a follow-up study. Here we used CLIP2 typing data on 117 post-Chernobyl PTCs from two cohorts of exposed patients with individual dose estimates and 24 non-exposed controls to investigate a possible quantitative dose-response relationship of the CLIP2 marker. The "Genrisk-T" cohort consisted of 45 PTCs and the "UkrAm" cohort of 72 PTCs. Both cohorts differed in mean dose (0.59 Gy Genrisk-T, 1.2 Gy UkrAm) and mean age at exposure (2 years Genrisk-T, 8 years UkrAm), whilst the median latency (16 years Genrisk-T, 18 years UkrAm) was comparable. We analyzed the association between the binary CLIP2 typing and continuous thyroid dose with logistic regression. A clear positive dose-response relationship was found for young PTC cases (AaO < 20 years, AaE < 5 years). In the elder age group a higher proportion of sporadic tumors is assumed due to an increased frequency of CLIP2 negative cases, suggesting different molecular mechanisms in sporadic and radiation-induced cases. This is further supported by the association of elder patients (AaO > 20 years) with positivity for BRAF V600E mutation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cancer Risk; Ionizing-radiation; Accident; Ukraine; Exposure; I-131; Signature; Reconstruction; Rearrangements; Children
ISSN (print) / ISBN 0143-3334
e-ISSN 1460-2180
Journal Carcinogenesis
Quellenangaben Volume: 36, Issue: 7, Pages: 748-756 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed