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Alloni, D.* ; Baiocco, G.* ; Babini, G.* ; Friedland, W. ; Kundrát, P. ; Mariotti, L.* ; Ottolenghi, A.*

Energy dependence of the complexity of DNA damage induced by carbon ions.

Radiat. Prot. Dosim. 166, 86-90 (2015)
Verlagsversion DOI
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To assess the complexity of DNA damage induced by carbon ions as a function of their energy and LET, 2-Gy irradiations by 100 keV u(-1)-400 MeV u(-1) carbon ions were investigated using the PARTRAC code. The total number of fragments and the yield of fragments of <30 bp were calculated. The authors found a particularly important contribution of DNA fragmentation in the range of <1 kbp for specific energies of <6 MeV u(-1). They also considered the effect of different specific energies with the same LET, i.e. before and after the Bragg peak. As a first step towards a full characterisation of secondary particle production from carbon ions interacting with tissue, a comparison between DNA-damage induction by primary carbon ions and alpha particles resulting from carbon break-up is presented, for specific energies of >1 MeV u(-1).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Quellenangaben Band: 166, Heft: 1-4, Seiten: 86-90 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed