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Karp, N.A.* ; Meehan, T.F.* ; Morgan, H.* ; Mason, J.C.* ; Blake, A.* ; Kurbatova, N.* ; Smedley, D.* ; Jacobsen, J.* ; Mott, R.F.* ; Iyer, V.* ; Matthews, P.* ; Melvin, D.G.* ; Wells, S.* ; Flenniken, A.M.* ; Masuya, H.* ; Wakana, S.* ; White, J.K.* ; Lloyd, K.C.K.* ; Reynolds, C.L.* ; Paylor, R.* ; West, D.B.* ; Svenson, K.L.* ; Chesler, E.J.* ; Hrabě de Angelis, M. ; Tocchini-Valentini, G.P.* ; Sorg, T.* ; Herault, Y.* ; Parkinson, H.* ; Mallon, A.M.* ; Brown, S.D.*

Applying the ARRIVE guidelines to an in vivo database.

PLoS Biol. 13:e1002151 (2015)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Experimental-design; Sex; Quality; Call
ISSN (print) / ISBN 1544-9173
e-ISSN 1545-7885
Journal PLoS Biology
Quellenangaben Volume: 13, Issue: 5, Pages: , Article Number: e1002151 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place San Francisco
Reviewing status Peer reviewed