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Glutathione peroxidase 4 (Gpx4) and ferroptosis: What's so special about it?

Mol. Cell. Oncol. 2:e995047 (2015)
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The system XC−/glutathione/glutathione peroxidase 4 axis pivotally controls ferroptosis, a recently described form of regulated, non-apoptotic cell death. Compelling evidence established that this cell death route is of high relevance not only for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cell death; Lipid peroxidation; Non-apoptotic cell death; Regulated necrosis
e-ISSN 2372-3556
Quellenangaben Band: 2, Heft: 3, Seiten: , Artikelnummer: e995047 Supplement: ,
Verlag Taylor & Francis
Begutachtungsstatus Peer reviewed