Open Access Green as soon as Postprint is submitted to ZB.
Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins.
Clin. Pharmacol. Ther. 86, 605-608 (2009)
The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0009-9236
Quellenangaben Volume: 86, Issue: 6, Pages: 605-608
Publishing Place Hoboken, NJ
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)