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Birkenfeld, A.L.* ; Jordan, J.* ; Hofmann, U.* ; Busjahn, A.* ; Franke, G.* ; Krüger, N.* ; Igel, S.* ; Mürdter, T.* ; Drescher, S.* ; Shi, S.* ; Engeli, S.* ; Schwab, M.* ; Eichelbaum, M.* ; Luft, F.C.* ; Fromm, M.F.*

Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins.

Clin. Pharmacol. Ther. 86, 605-608 (2009)
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Open Access Green as soon as Postprint is submitted to ZB.
The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0009-9236
e-ISSN 1532-6535
Quellenangaben Volume: 86, Issue: 6, Pages: 605-608 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken, NJ
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)