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Hampel, R. ; Peters, A. ; Beelen, R.* ; Brunekreef, B.* ; Cyrys, J. ; de Faire, U.* ; de Hoogh, K.* ; Fuks, K.* ; Hoffmann, B.* ; Hüls, A.* ; Imboden, M.* ; Jedynska, A.* ; Kooter, I.M.* ; Koenig, W.* ; Künzli, N.* ; Leander, K.* ; Magnusson, P.* ; Männistö, S.* ; Penell, J.* ; Pershagen, G.* ; Phuleria, H.* ; Probst-Hensch, N.* ; Pundt, N.* ; Schaffner, E.* ; Schikowski, T.* ; Sugiri, D.* ; Tiittanen, P.* ; Tsai, M.Y.* ; Wang, M.* ; Wolf, K. ; Lanki, T.*

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts.

Environ. Int. 82, 76-84 (2015)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses. OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects. METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass. RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5. CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Escape ; Elemental Components ; Inflammation ; Long-term Exposure ; Particulate Matter ; Transphorm; Use Regression-models; Outdoor Air-pollution; Cardiovascular Mortality; Epidemiologic Evidence; Systemic Inflammation; Chemical-constituents; Pm2.5 Absorbency; Chronic Exposure; Escape Project; Fine
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Quellenangaben Band: 82, Heft: , Seiten: 76-84 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Begutachtungsstatus Peer reviewed