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Lymphoid progenitors as candidate cancer stem cells in AML: New perspectives.

Cell Cycle 6, 543-545 (2007)
Open Access Green as soon as Postprint is submitted to ZB.
Mouse models have demonstrated that both hematopoietic stem cells (HSCs) as well as downstream myeloid progenitors can be targets of transformation in AML. We recently showed in a murine model of the CALM/AF10 fusion gene positive leukemia, that progenitors with lymphoid characteristics can be leukemic stem cell (LSC) candidates in AML. We could demonstrate that the LSC candidate in the CALM/AF10 murine model was positive for the lymphoid associated surface antigen B220, which was not expressed by the leukemic bulk or the normal HSC pool. This offers the intriguing possibility to target the LSCs with antibodies that spare the normal stem cell.
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Publication type Article: Journal article
Document type Scientific Article
Keywords CALM/AF10; leukemic stem cells; AML; targeted therapy
ISSN (print) / ISBN 1538-4101
e-ISSN 1551-4005
Journal Cell Cycle
Quellenangaben Volume: 6, Issue: 5, Pages: 543-545 Article Number: , Supplement: ,
Publisher Landes Bioscience
Reviewing status Peer reviewed