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Kreyling, W.G. ; Abdelmonem, A.M.* ; Ali, Z.* ; Alves, F.* ; Geiser, M.* ; Haberl, N. ; Hartmann, R.* ; Hirn, S. ; de Aberasturi, D.J.* ; Kantner, K.* ; Khadem-Saba, G. ; Montenegro, J.M.* ; Rejman, J.* ; Rojo, T.* ; de Larramendi, I.R.* ; Ufartes, R.* ; Wenk, A. ; Parak, W.J.*

In vivo integrity of polymer-coated gold nanoparticles.

Nat. Nanotechnol. 10, 619-623 (2015)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their physicochemical properties, and it is well known that their colloidal properties may change upon internalization by cells. While the stability of such nanoparticles is typically assayed in simple in vitro tests, their stability in a mammalian organism remains unknown. Here, we show that firmly grafted polymer shells around gold nanoparticles may degrade when injected into rats. We synthesized monodisperse radioactively labelled gold nanoparticles ((198)Au) and engineered an (111)In-labelled polymer shell around them. Upon intravenous injection into rats, quantitative biodistribution analyses performed independently for (198)Au and (111)In showed partial removal of the polymer shell in vivo. While (198)Au accumulates mostly in the liver, part of the (111)In shows a non-particulate biodistribution similar to intravenous injection of chelated (111)In. Further in vitro studies suggest that degradation of the polymer shell is caused by proteolytic enzymes in the liver. Our results show that even nanoparticles with high colloidal stability can change their physicochemical properties in vivo.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cells; Biodistribution; Cytotoxicity; Toxicity; Depends; Damage
ISSN (print) / ISBN 1748-3387
e-ISSN 1748-3395
Zeitschrift Nature Nanotechnology
Quellenangaben Band: 10, Heft: 7, Seiten: 619-623 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus