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Brenner, T.* ; Rosenhagen, C.* ; Steppan, J.* ; Lichtenstern, C.* ; Weitz, J.* ; Bruckner, T.* ; Martin, E.O.* ; Hoffmann, U.* ; Weigand, M.A.* ; Hofer, S.*

Redox responses in patients with sepsis: High correlation of thioredoxin-1 and macrophage migration inhibitory factor plasma levels.

Mediators Inflamm. 2010:985614 (2010)
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Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock (n = 15) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers (n = 18) were collected once; samples from postoperative patients (n = 28) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: r(sp) = 0.720, ρ = 0.698/t24: r(sp) = 0.771, ρ = 0.949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0962-9351
e-ISSN 1466-1861
Quellenangaben Volume: 2010, Issue: , Pages: , Article Number: 985614 Supplement: ,
Publisher Hindawi
Publishing Place Sylvania, Ohio
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)