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Radiation-induced genetic effects and the Chernobyl Nuclear Power Plant accident.

Vortrag: ESPR, 50th Annual Meeting, 9-12 October 2009, Hamburg, Germany. (2009)
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Background and aims: The disaster at the Nuclear Power Plant in Chernobyl in April 1986 resulted in the exposure of a large number of people to ionizing radiation that varied substantially, creating a new situation for epidemiology. We aim to demonstrate lasting genetic or reproductive detrimental health effects after Chernobyl in moderately and highly affected European countries.   Methods: Time trend analyses and spatial-temporal analyses based on logistic regression.    Results: Long-term dose dependent impacts of radioactive fallout after Chernobyl on stillbirths, birth defects, and the human sex ratio at birth have been found. For example, from nearly all published data concerning Down’s syndrome, long term increases after Chernobyl may be seen. Significant ecological relative risks for stillbirths and birth defects are in the range of 1.005 to 1.020 per kBq/m2 137Cs. A relative risk coefficient of 1.010 per kBq/m2 137Cs translates to a preliminary relative risk coefficient of 1.60 per mSv/a. German district by district data imply a sex odds ratio of 1.015 per mSv/a. Furthermore, there are striking jumps in the sex ratio in 1987 in several central and eastern European countries.   Conclusion: The effects of ionizing radiation at doses below 10 mSv are little understood. Recent epidemiologic evidence suggests that there is harm at doses below 1 mSv or that the established dose concept is invalid.
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Publication type Other: Lecture
Conference Title ESPR, 50th Annual Meeting
Conference Date 9-12 October 2009
Conference Location Hamburg, Germany