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Scherb, H. ; Voigt, C.*

Radiation-induced genetic effects and ecological dose-response analyses.

Vortrag: 20th Annual Conference of The International Environmetrics Society, 5-9 July 2009, Bologna, Italy. (2009)
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The effects of ionizing radiation at doses below 10 mSv are still little understood. Recent epidemiologic evidence suggests that there is harm in the dose range of a few mSv or even below 1 mSv. The disaster at the Nuclear Power Plant in Chernobyl in April 1986 resulted in the exposure of a large number of people in Europe to ionizing radiation that varied substantially, creating a new situation for epidemiology. In many data sets from central, eastern, and northern parts of Europe, absolute or relative increases of birth defects, stillbirths, and the human sex ratio at birth after 1986 were observed. Marked jumps in the temporal trends of unfortunate pregnancy outcome indicators are supported by results from analytical ecological dose-response analyses involving a spatial dimension represented by region-(district)-specific exposure data. Long-term dose dependent detrimental impacts of radioactive fallout after Chernobyl on pertinent genetic health indicators (stillbirths, birth defects, and the human sex ratio at birth) have been found. For example, from nearly all published data concerning Down’s syndrome in Europe, from 1981 to 1992, long-term increases after Chernobyl may be seen. Typical ecological relative risks for stillbirth and certain types of birth defects (Down syndrome, malformations of the heart, deformities) are in the range 1.2 – 2.5 per mSv/a. The sex odds ratio per mSv/a has been found in the range of 1.01 – 1.04, depending on whether one considers long-term or short-term effects.
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Publikationstyp Sonstiges: Vortrag
Konferenztitel 20th Annual Conference of The International Environmetrics Society
Konferzenzdatum 5-9 July 2009
Konferenzort Bologna, Italy