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Systematic phenotyping of mouse mutants in the German Mouse Clinic.

Vortrag: Human Brain Proteome Meeting, 9-11 January 2007, Schloss Rauischholzhausen, Germany. (2007)
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The German Mouse Clinic (GMC), located at the GSF Research Centre in Munich, offers a comprehensive, standardized phenotype analysis of mouse mutant lines by specialists from various disciplines and from different institutions in Germany, working side by side at one place. The phenotypic screens focus on the areas of allergy, behavior, bone and cartilage, cardiovascular diseases, clinical chemistry, eye development and vision, energy metabolism, immunology, lung function, neurology, nociception, molecular phenotyping, steroid-metabolism, and pathology. Within the European initiative EUMORPHIA, we have standardized and validated our screening procedure. In the near future, our centre will be part of the pan-European mouse phenotyping initiative EUMODIC. More than 50 mutant lines have been analyzed in the primary screen, and baseline data for 9 mouse inbred strains and hybrids are available. From the mutant lines, which completed the primary screen, we found new or additional phenotypes in 47 mutant lines. At least subtle changes were detected in almost every mutant line. Secondary screens were recommended for 45 mutant lines.   As a next step, we will include genotype-environment-interactions in the analysis of the mutant lines. We will switch from a constant to a variable environment by establishing “environmental platforms” with different standardized challenge experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences.
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Publikationstyp Sonstiges: Vortrag
Konferenztitel Human Brain Proteome Meeting
Konferzenzdatum 9-11 January 2007
Konferenzort Schloss Rauischholzhausen, Germany