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Nogueira, P.* ; Zankl, M. ; Schlattl, H. ; Vaz, P.*

High resolution voxel model of the human eye.

Vortrag: Joint Topical Meeting of the Radiation Protection and Shielding Division of the American Nuclear Society, 18-23 April 2010, Las Vegas, USA. (2010)
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The radiation induced posterior subcapsular cataract has long been documented as a major ocular complication (1). This ocular opacification is the result of a radiation injury to the eye lens epithelium, and it is the disruption of the normal mitosis of the epithelium cells that ultimately leads to the production of a granular material instead of new lens fibres (2, 3, 4). The relation between the exposure to radiation and the development of cataracts based on studies of cataract data 19 years after the atomic bombings in Hiroshima, Japan, was considered a deterministic effect with a dose-response threshold of approximately 1.5 Gy (5, 6, 7). Several recent epidemiological studies (8, 9, 10, 11) showed that the lens of the eye may be more radiosensitive than previously assumed. Moreover, a recent re-analysis among the atomic bomb survivors provided no significant evidence for a dose-response threshold (12). These new studies together with the uncertainties of the mechanisms of the cataract development led the ICRP to highlight the need for a detailed re-appraisal of the radiosensitivity of the lens of the eye (13). Monte Carlo methods and appropriate anatomical models are an indispensable tool for the assessment of the doses to the lens. The ICRP now uses reference computational voxel phantoms for calculating male and female equivalent doses in organs and tissues (13). However, the sensitive zone of the eye lens is a cell layer present only in the anterior eye lens (eye lens epithelium) and the voxel dimension of the ICRP reference computational phantoms is too large to permit calculations of the doses in the eye lens epithelium.
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Publikationstyp Sonstiges: Vortrag
Konferenztitel Joint Topical Meeting of the Radiation Protection and Shielding Division of the American Nuclear Society
Konferzenzdatum 18-23 April 2010
Konferenzort Las Vegas, USA