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Giussani, A.* ; Cantone, M.C.* ; Höllriegl, V. ; Oeh, U. ; Tavola, F.* ; Veronese, I.*

Stable tracer investigations for validation and upgrading of the biokinetic model for molybdenum.

Vortrag: Internal Dosimetry of Radionuclides, 2-5 Ocotber 2006, Montpellier, France. (2006)
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Molybdenum is considered an essential element for humans, and is also of interest for radiation protection with respect to its isotope 99Mo. However, like for many other elements of radiological importance, limited information is available on its biokinetics in humans, and the reliability and realism of the recommended biokinetic and dosimetric models may thus be limited. Recently, a broad study was undertaken, with the aim to investigate intestinal uptake, systemic kinetics and urinary excretion of molybdenum in healthy human volunteers. A total of 63 experiments with 17 volunteers were performed administering stable isotopes of molybdenum as tracers and measuring their concentrations in blood plasma and urine samples by means of activation analysis and mass spectrometry as analytical techniques. In this work a comprehensive overview of the results of the whole study will be presented and discussed with regard to the predictions of the current ICRP model. Specifically, intestinal absorption was observed to be very effective and rapid, although rate and extent of uptake were strongly dependent on the form and amount of administration. The data did not support any evidence of retention in the gut walls or of absorption from lower sections of the intestine. Moreover, the measured urinary excretion patterns diverged significantly from the current predictions, and this aspect might be relevant when using the model for retrospective intake assessments in case of an accident. On the basis of the experimental data a more realistic compartmental structure was outlined. The influence of amount, form and modality of administration on the model and on its parameters will be discussed. In particular, great consideration will be given to the mechanisms which control both intestinal absorption and urinary excretion, thus regulating total body molybdenum content. The consequences of the model upgrading with regard to dose estimation and to interpretation of bioassay data will also be presented.
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Publikationstyp Sonstiges: Vortrag
Konferenztitel Internal Dosimetry of Radionuclides
Konferzenzdatum 2-5 Ocotber 2006
Konferenzort Montpellier, France