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Genetics of human metabolism: An update.

Hum. Mol. Genet. 24, R93-R101 (2015)
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Genome-wide association studies with metabolomics (mGWAS) identify genetically influenced metabotypes (GIMs), their ensemble defining the heritable part of every human's metabolic individuality. Knowledge of genetic variation in metabolism has many applications of biomedical and pharmaceutical interest, including the functional understanding of genetic associations with clinical endpoints, design of strategies to correct dysregulations in metabolic disorders, and the identification of genetic effect modifiers of metabolic disease biomarkers. Furthermore, it has been shown that GIMs provide testable hypotheses for functional genomics and metabolomics and for the identification of novel gene functions and metabolite identities. mGWAS with growing sample sizes and increasingly complex metabolic trait panels are being conducted, allowing for more comprehensive and systems based downstream analyses. The generated large data sets of genetic associations can now be mined by the biomedical research community and provide valuable resources for hypothesis driven studies. In this review, we provide a brief summary of the key aspects of mGWAS, followed by an update of recently published mGWAS. We then discuss new approaches of integrating and exploring mGWAS results and finish by presenting selected applications of GIMs in recent studies.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Quellenangaben Volume: 24, Issue: R1, Pages: R93-R101 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed