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Barrios, C.* ; Zierer, J. ; Gudelj, I.* ; Stambuk, J.* ; Ugrina, I.* ; Rodriguez, E.* ; Soler, M.J.* ; Pavić, T.* ; Simurina, M.* ; Keser, T.* ; Pučić-Baković, M.* ; Mangino, M.* ; Pascual, J.* ; Spector, T.D.* ; Lauc, G.* ; Menni, C.*

Glycosylation profile of IgG in moderate kidney dysfunction.

J. Am. Soc. Nephrol. 27, 933-941 (2016)
Verlagsversion Anhang DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5×10(-4)) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Clinical Nephrology ; Glycation ; Renal Function Decline; Fc-gamma-riiia; Serum Igg; Antiinflammatory Activity; Rheumatoid-arthritis; Inflammatory Diseases; Immunoglobulin-g; Galactosylation; Nephropathy; Complement; Binding
ISSN (print) / ISBN 1046-6673
e-ISSN 1533-3450
Quellenangaben Band: 27, Heft: 3, Seiten: 933-941 Artikelnummer: , Supplement: ,
Verlag American Society of Nephrology
Verlagsort Washington
Begutachtungsstatus Peer reviewed